Actualizing the Untapped Potential of the Innate Immune System

Affimed’s approach to advancing immuno-oncology

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Events

30Sep

NK2019

September 30 - October 3, 2019 (Luxembourg)

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Our Mission

Our mission at Affimed is to create novel therapeutic options for patients suffering from cancer and other life-threatening diseases through activating innate immunity.

With our differentiated approach to arming the body’s innate immune systems, we are focused on delivering new treatments beyond the limitations of existing therapies.

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Affimed (NASDAQ: AFMD) pioneers immune cell engagement, employing its insights and scientific expertise to harness the body’s innate immune systems in the fight against cancer and other life-threatening diseases. Our proprietary ROCK® (Redirected Optimized Cell Killing) platform allows for the modular design of tetravalent bi- and multi-specific antibodies, including first-in-class innate and adaptive cell engager products.

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Our Approach

Redirecting immune cells to kill tumor cells

With our differentiated approach to arming the body’s innate immune systems, we are focused on delivering new treatments beyond the limitations of existing therapies.
We have used our extensive drug development expertise to generate antibody candidates tailored to different indications, leveraging our proprietary ROCK® platform. ROCK® enables generation of antibodies with the potential for competitive advantages over traditional therapies including highly customizable antibody engagers for tailored treatment options and generation of antibodies with variable pharmacokinetic (PK) profiles.

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Our Pipeline

Diverse pipeline of differentiated and versatile engagers to activate innate immunity

A number of clinical and preclinical programs are in development based on the ROCK® platform and our tetravalent bispecific immune cell engagers have already shown a favorable safety profile and promising signs of therapeutic efficacy.

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Innate Cell Engagers

AFM13

Disease Target CD30Immune Cell Target CD16A
Hodgkin lymphoma + PD-1
Phase 1
Hodgkin lymphoma
Phase 2
CD30+ lymphoma + adoptive NK cells
Pre-IND
CD30+ lymphoma
Phase 2

AFM24

Disease Target EGFRwtImmune Cell Target CD16A
Solid tumors
Pre-IND

AFM26

Disease Target BCMAImmune Cell Target CD16A
Multiple Myeloma
Pre-IND
Affimed programs
Partnered programs

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