Actualizing the Untapped Potential of the Innate Immune System

Affimed’s approach to advancing immuno-oncology

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Our Mission

We are a team of innate immunity experts unrelenting in our efforts to change the meaning of cancer

With our differentiated approach to arming the body’s innate immune systems, we are focused on delivering new treatments beyond the limitations of existing therapies.

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Affimed (NASDAQ: AFMD) pioneers immune cell engagement, employing its insights and scientific expertise to harness the body’s innate immune systems in the fight against cancer and other life-threatening diseases. Our proprietary ROCK® (Redirected Optimized Cell Killing) platform allows for the modular design of tetravalent bi- and multi-specific antibodies, including first-in-class innate and adaptive cell engager products.

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Our Approach

Redirecting innate cells to recognize and kill tumor cells

We are actualizing the next advancement in immuno-oncology (I-O) through our proprietary ROCK® platform, which stands for Redirected Optimized Cell Killing. Our new approach to build ROCK® based innate cell engagers aims to treat a broad range of hematologic and solid tumors by countering tumor immune evasion through activating a patient’s own innate immune system.

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Our Pipeline

Targeting hematological and solid tumors with differentiated and versatile innate cell engagers

Our ROCK® platform-designed tetravalent bispecific innate cell engagers are being studied in a number of clinical and preclinical programs. These innate cell engagers are the first to demonstrate a favorable safety profile and promising signs of therapeutic efficacy.

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Innate Cell Engagers

AFM13

Disease Target CD30
CD30-positive T cell lymphoma
Phase 2
Peripheral T cell lymphoma
Phase 2
Transformed mycosis fungoides
Phase 2
Hodgkin lymphoma (post BV and post anti-PD-1)
Phase 2

AFM13 + adoptive NK cells

Disease Target CD30
CD30-positive lymphoma
Phase 1

AFM13 + anti-PD-1

Disease Target CD30
Hodgkin lymphoma (post BV)
Phase 1

AFM24

Disease Target EGFR
Solid tumors
IND Cleared

AFM26

Disease Target BCMA
Multiple Myeloma
Pre-IND

AFM28 and AFM32

Disease Target Undisclosed
Undisclosed
Pre-IND

Genentech

Disease Target Undisclosed
Multiple Programs
Pre-IND
Affimed programs
Partnered programs

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