Affimed (Nasdaq: AFMD) is a clinical stage biopharmaceutical company which engineers targeted immunotherapies, seeking to improve patient outcomes through the power of innate immunity. Affimed’s fit-for-purpose ROCK® platform allows innate immune engagers to be designed for specific patient populations. We are developing single and combination therapies to treat cancers.

To strengthen our highly motivated Translational Immunobiology Department in Heidelberg, Germany, we are looking for a

Head of Innate Immune Cell Therapies (f/m/d)

(Reference No. R2224)

Apply now


  • Lead a multifunctional team to evaluate and translate biological mechanisms of innate immune cells in combination with Innate Cell Engagers (ICE®) to product development and CMC teams
  • Build scientific rationale and drive experimental work to establish combination therapies of Affimed’s ICE® and adoptive cellular therapy
  • Lead and establish R&D scale production of innate immune cell preparations and drive the evaluation of novel combination regimens in vitro and in vivo
  • Work collaboratively in a matrix environment and act as a subject matter expert to preclinical teams, cross-functional program teams, and management team
  • Develop novel disease-relevant hypotheses and innovative drug concepts with a focus on innate immunity and drive publication of experimental results


  • Advanced degree (M.D. or Ph.D. in life sciences) with relevant experience in cellular cancer immunotherapies
  • At minimum, five years of research leadership experience in a clinical, biotechnology, or pharmaceutical industry setting in the context of the development of cellular therapies in immuno-oncology
  • Experience in leading a research laboratory driving projects according to timelines, budget and quality
  • Experience in large-scale preparation and functional characterization of innate immune cells such as NK cells, gamma-delta T cells and/or macrophages and detailed knowledge about related processing equipment such as CliniMACS, CliniMACS Prodigy, G-Rex
  • Specific knowledge on genetic modification of innate immune cells is a plus
  • Good understanding of regulatory and quality requirements for GMP-compliant production of cell products is a plus
  • Strong capabilities in relationship building with team members and external partners, ensuring successful collaboration
  • Excellent communication skills covering a broad range of audiences, including research teams, cross-functional program teams and management team
  • Fluent in English (oral & written), German language skills are a plus

We Offer

  • Multifaceted and responsible position, working on innovative projects in an international environment with strong team spirit
  • Space for commitment and personal initiative with the possibility for personal and professional growth
  • Attractive, performance-related compensation package and further benefits:
    • Employee financial participation in form of stock options
    • Attractive pension allowance from employer
    • Low-cost use of local public transportation (Jobticket)
    • Free parking spaces
    • Bike Leasing
  • Flexible working time, possibility to partially work remotely (depending on function)
  • Regular company events such as Culture Day, Summer Get-Together, participation in charity events

For any queries, please contact Susanne Hering (Tel: 06221 6743 675, e-mail:

We are looking forward to receive your application including motivation letter and salary expectations.

December 2022

Your application