Affimed (Nasdaq: AFMD) is a clinical stage biopharmaceutical company which engineers targeted immunotherapies, seeking to improve patient outcomes through the power of innate immunity. Affimed’s fit-for-purpose ROCK® platform allows innate immune engagers to be designed for specific patient populations. We are developing single and combination therapies to treat cancers.

To strengthen our highly motivated Translational Research and Innovation Team in Heidelberg, Germany, we are looking for a

Head In Vivo Pharmacology (f/m/d)

(Reference No. R2106)

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  • Lead the in vivo research platform that comprises antibody-based assets in immuno-oncology focusing on therapeutic target validation, drug candidate selection and characterization, translational biology and indication expansion
  • Influence strategy in discovery and early clinical development as part of the Translational Research and Innovation Team and in cross-functional development teams
  • Seamlessly integrate with cross-functional leaders including but not limited to Preclinical Development, Clinical Development, and Project Team Leaders to continuously align on project priorities, objectives and outcomes
  • Outreach, relationship building, design of collaborative research workplans, study monitoring, technical optimization and maintaining efficient workflow under tight timelines
  • Ability to foresee possible obstacles and roadblocks
  • To develop and implement timely contingency plans is crucial
  • Be responsible for overseeing the development, validation and implementation of proof-of-concept animal models
  • Design, execute and interpret in vivo experiments to optimize drug candidate selection and explore therapeutic potential of drug candidates
  • Drive and manage externalization of work at CROs
  • Line management responsibilities of 2 senior scientists


  • Ph.D. or MD/Ph.D. qualified with established relevant biotech or pharmaceutical industry experience
  • 5-10 years of experience in developing pharmacodynamic mechanistic animal models to support translational disease relevant strategies in disease models of hematological and/or solid cancers would be preferred
  • Established scientific reputation in the field of innate immunity and in vivo cancer/IO models as evidenced by publication track record
  • Experience in advancement of drug candidates through project milestones
  • Experience in working in cross-functional and matrixed research and translational teams
  • Experience in leading and managing groups in biotech/pharma environment
  • Able to establish, maintain and manage effective collaborations with external partners
  • Excellent communication skills at both detailed and summarized levels
  • Team player with ability to conduct independent research
  • Able to quickly prioritize deliverables according to team and business requirements.
  • Full proficiency in English (oral and written), German language skills are a plus


The successful candidate will have the unique opportunity to work in a dynamic, highly motivated, multidisciplinary, and collegial team.
For any queries, please contact Susanne Hering (Tel: 06221 6743 675, e-mail:

Heidelberg, April 2021

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