| In this subgroup (N=13), 3 partial responses (≥50% tumor shrinkage) and 7 cases with stable disease were observed, resulting in an overall disease control rate of 77%. Of note, 6 of 7 patients that were refractory to brentuximab vedotin had a stabilization of their disease, an indication that this patient population may also benefit from AFM13 treatment. Based on these data a phase 2 study is being prepared with an optimized dosing regimen designed to demonstrate the full therapeutic potential of AFM13 in relapsed/refractory HL patients.
In September 2013, Affimed signed an agreement with the Leukemia and Lymphoma Society (LLS) in which the LLS committed to co-funding of the phase 2 development of AFM13 of up to $4.4 million over 2 years. In doing so, the LLS recognized the critical need for safer and more durable therapies for HL. The LLS is committed to advancing breakthrough therapies, particularly for patients with unmet medical needs. The LLS is the world’s largest voluntary health agency dedicated to blood cancer; its mission is: cure leukemia, lymphoma, Hodgkin’s disease and myeloma, and improve the quality of life of patients and their families.